Genetic Alterations in Papillary Thyroid Carcinoma With Hashimoto^'s Thyroiditis： ANK3, an Indolent Maintainer of Papillary Thyroid Carcinoma.

ABSTRACT: Hashimoto's thyroiditis (TH) is a risk factor for the occurrence of papillary thyroid carcinoma (PTC), which is considered to be the most common type of thyroid cancer. In recent years, the prevalence of PTC with TH has been increasing, but little is known about the genetic alteration in PTC with TH. This study analyzed the mutation spectrum and mutation signature of somatic single nucleotide variants (SNV) for 10 non-tumor and tumor pair tissues of PTC with TH using whole-exome sequencing. The ANK3 protein expression was evaluated by immunohistochemistry in PTC with TH and PTC samples. Moreover, the functional role of ANK3 in PTC cells was determined by CCK-8 proliferation assay, colony formation assays, cell cycle analysis, cell invasion and migration and in vivo study through ove

SUBMITTER: Zeng C 

PROVIDER: S-EPMC9133634 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature