Beta-diversity distance matrices for microbiome sample size and power calculations - How to obtain good estimates.

ABSTRACT: In microbiome studies, researchers often wish to compare the taxa count distributions between groups of samples. Commonly-used corresponding methods of analysis are built on examining distance matrices, where distances describe the beta-diversity between samples. Analyses then compare the distribution of distances within groups to the distributions between groups. However, when performing a priori sample size or power calculations for such study designs, appropriate within and between group distance distributions can be challenging to obtain. When available, pilot study data, or data from prior studies of similar design should provide realistic distance estimates. However, when these are not available, distances can be extracted from available studies where one can assume similar be

SUBMITTER: By IMPACTT investigators 

PROVIDER: S-EPMC9133771 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature