Dataset Information

Triglyceride-Glucose Index Is a Useful Marker for Predicting Future Cardiovascular Disease and Mortality in Young Korean Adults: A Nationwide Population-Based Cohort Study.

ABSTRACT:

Objective

The triglyceride-glucose (TyG) index, the product of fasting triglycerides and glucose, is a useful and cost-effective marker of insulin resistance (IR). Furthermore, the TyG index is a known IR screening tool in healthy young adults but not in those with atherosclerotic cardiovascular disease (CVD). Thus, this study aimed to evaluate the TyG index as a predictor of CVD in healthy young adults.

Methods

This study enrolled 6,675,424 adults aged 20-39 years without CVD from the National Health Information Database. We categorized them by TyG index quartile from 2009-2017. The study outcomes were stroke, myocardial infarction (MI), and mortality. All outcomes were analyzed by Cox proportional hazards regression analysis while controlling for baseline covariates.

Results

During a mean 7.4 years of follow-up, 8,506 cases of stroke, 12,312 cases of MI, and 22,667 deaths were recorded. Multivariable-adjusted hazard ratios (HRs) for participants in the highest TyG index quartile demonstrated that they were at higher risk for stroke (HR, 1.253; 95% confidence interval [CI], 1.167-1.346), MI (HR, 1.258; 95% CI, 1.187-1.334), and mortality (HR, 1.151; 95% CI, 1.104-1.200) than those in the lowest TyG index quartile independent of age, sex, smoking, alcohol consumption, physical activity, income, body mass index, blood pressure, and total cholesterol. The HRs for outcomes in the highest quartiles were higher when the TyG index was applied than when triglyceride or fasting glucose alone was applied.

Conclusion

TyG index, a simple measure reflecting IR, can predict CVD and mortality in young and healthy populations.

SUBMITTER: Cho YK

PROVIDER: S-EPMC9133778 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Triglyceride-Glucose Index Is a Useful Marker for Predicting Future Cardiovascular Disease and Mortality in Young Korean Adults: A Nationwide Population-Based Cohort Study.

Cho Yun Kyung YK Han Kyung-do KD Kim Hwi Seung HS Jung Chang Hee CH Park Joong-Yeol JY Lee Woo Je WJ

Journal of lipid and atherosclerosis 20220421 2

<h4>Objective</h4>The triglyceride-glucose (TyG) index, the product of fasting triglycerides and glucose, is a useful and cost-effective marker of insulin resistance (IR). Furthermore, the TyG index is a known IR screening tool in healthy young adults but not in those with atherosclerotic cardiovascular disease (CVD). Thus, this study aimed to evaluate the TyG index as a predictor of CVD in healthy young adults.<h4>Methods</h4>This study enrolled 6,675,424 adults aged 20-39 years without CVD fro ...[more]

PMID: 35656153

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Project description:ObjectiveCurrent literature is deficient in robust evidence delineating the correlation between the triglyceride glucose-body mass index (TyG-BMI) and the incidence of stroke. Consequently, this investigation seeks to elucidate the potential link between TyG-BMI and stroke risk in a cohort of middle-aged and senior Chinese individuals.MethodsThis study employs longitudinal data from four waves of the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2011, 2013, 2015, and 2018, encompassing 8,698 participants. The CHARLS cohort was assembled using a multistage probability sampling technique. Participants underwent comprehensive evaluations through standardized questionnaires administered via face-to-face interviews. Our analytic strategy involved the application of Cox proportional hazards regression models to investigate the association between TyG-BMI and the risk of stroke. To discern potential non-linear relationships, we incorporated Cox proportional hazards regression with smooth curve fitting. Additionally, we executed a battery of sensitivity and subgroup analyses to validate the robustness of our findings.ResultsOur study utilized a multivariate Cox proportional hazards regression model and found a significant correlation between the TyG-BMI and the risk of stroke. Specifically, a 10-unit increase in TyG-BMI corresponded to a 4.9% heightened risk of stroke (HR = 1.049, 95% CI 1.029-1.069). The analysis also uncovered a non-linear pattern in this relationship, pinpointed by an inflection point at a TyG-BMI value of 174.63. To the left of this inflection point-meaning at lower TyG-BMI values-a 10-unit hike in TyG-BMI was linked to a more substantial 14.4% rise in stroke risk (HR 1.144; 95% CI 1.044-1.253). Conversely, to the right of the inflection point-at higher TyG-BMI values-each 10-unit increment was associated with a smaller, 3.8% increase in the risk of stroke (HR 1.038; 95% CI 1.016-1.061).ConclusionsIn the middle-aged and elderly Chinese population, elevated TyG-BMI was significantly and positively associated with stroke risk. In addition, there was also a specific non-linear association between TyG-BMI and stroke (inflection point 174.63). Further reduction of TyG-BMI below 174.63 through lifestyle changes and dietary control can significantly reduce the risk of stroke.

Project description:BackgroundThe triglyceride-glucose (TyG) index has emerged as a validated and cost-effective indicator of insulin resistance (IR). Given the significant association between visceral obesity and IR, this study aimed to investigate the utility of the TyG index in estimating visceral obesity in patients with gastric cancer (GC).MethodsThe visceral fat area (VFA), subcutaneous fat area (SFA), and VFA-to-SFA ratio (VSR) were determined through the analysis of CT images at the lumbar 3 level. The definition of visceral obesity was established as VFA ≥ 100 cm2. The association between the TyG index and visceral obesity was assessed using logistic regression analysis and restricted cubic splines. The diagnostic performance for identifying visceral obesity was evaluated by calculating the area under the Receiver Operating Characteristics curve (AUC).ResultsThe cross-sectional study enrolled a total of 314 patients with GC, among whom 159 (50.64%) were identified as having visceral obesity. The TyG index was positively correlated with VFA (r = 0.45, p < 0.001), SFA (r = 0.23, p < 0.001), and VSR (r = 0.35, p < 0.001). However, subsequent multivariate linear regression analysis demonstrated that the TyG index was significantly associated with VFA and VSR, but not SFA. After adjusting for potential confounding factors, the TyG index remained independently associated with visceral obesity (OR = 2.54, 95% CI: 1.32-4.89, p = 0.005) and demonstrated a significantly positive linear correlation with visceral obesity in patients with GC (p-value for non-linearity = 0.116). TyG-BMI, the combination index of TyG and BMI, showed the highest predictive power in identifying visceral obesity in GC patients (AUC = 0.849, 95% CI: 0.807-0.890, p < 0.001). The subgroup analysis revealed a significantly stronger positive association between the TyG index and visceral obesity in patients with BMI ≥ 25 kg/m2 (p for interaction = 0.049).ConclusionThe TyG index exhibited a significant association with visceral obesity and proved to be a valuable predictor for visceral obesity when combined with BMI in patients with GC.

Dataset Information

Triglyceride-Glucose Index Is a Useful Marker for Predicting Future Cardiovascular Disease and Mortality in Young Korean Adults: A Nationwide Population-Based Cohort Study.

Objective

Methods

Results

Conclusion

Publications

Triglyceride-Glucose Index Is a Useful Marker for Predicting Future Cardiovascular Disease and Mortality in Young Korean Adults: A Nationwide Population-Based Cohort Study.

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