Dataset Information

Volatile Organic Compounds Analysis as a Potential Novel Screening Tool for Breast Cancer: A Systematic Review.

ABSTRACT:

Introduction

An early diagnosis is crucial in reducing mortality among people who have breast cancer (BC). There is a shortfall of characteristic early clinical symptoms in BC patients, highlighting the importance of investigating new methods for its early detection. A promising novel approach is the analysis of volatile organic compounds (VOCs) produced and emitted through the metabolism of cancer cells.

Methods

The purpose of this systematic review is to outline the published research regarding BC-associated VOCs. For this, headspace analysis of VOCs was explored in patient-derived body fluids, animal model-derived fluids, and BC cell lines to identify BC-specific VOCs. A systematic search in PubMed and Web of Science databases was conducted according to the PRISMA guidelines.

Results

Thirty-two studies met the criteria for inclusion in this review. Results highlight that VOC analysis can be promising as a potential novel screening tool. However, results of in vivo, in vitro and case-control studies have delivered inconsistent results leading to a lack of inter-matrix consensus between different VOC sampling methods.

Discussion

Discrepant VOC results among BC studies have been obtained, highly due to methodological discrepancies. Therefore, methodological issues leading to disparities have been reviewed and recommendations have been made on the standardisation of VOC collection and analysis methods for BC screening, thereby improving future VOC clinical validation studies.

SUBMITTER: Leemans M

PROVIDER: S-EPMC9134002 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Volatile Organic Compounds Analysis as a Potential Novel Screening Tool for Breast Cancer: A Systematic Review.

Leemans Michelle M Bauër Pierre P Cuzuel Vincent V Audureau Etienne E Fromantin Isabelle I

Biomarker insights 20220523

<h4>Introduction</h4>An early diagnosis is crucial in reducing mortality among people who have breast cancer (BC). There is a shortfall of characteristic early clinical symptoms in BC patients, highlighting the importance of investigating new methods for its early detection. A promising novel approach is the analysis of volatile organic compounds (VOCs) produced and emitted through the metabolism of cancer cells.<h4>Methods</h4>The purpose of this systematic review is to outline the published re ...[more]

PMID: 35645556

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Project description:BackgroundThe identification of volatile organic compounds (VOCs) in exhaled breath has garnered significant research attention as a means of screening and diagnosing lung cancer in recent decades. However, there is no universally accepted protocol for the collection of breath samples to measure VOCs in the clinical context. The purpose of this study was to summarize the current sampling techniques used to obtain VOCs from exhaled breath specifically in the context of lung cancer screening and diagnosis.MethodsWe searched four major literature databases (PubMed, Embase, Web of Science, and The Cochrane Library) to identify studies published from January 1985 to October 2023. Trials that analyzed endogenous VOCs within exhaled breath to screen or diagnose lung cancer were included. The methods used for exhaled breath collection were divided under the following headings: before collection (patient preparation, environmental preparation, contamination detection), during collection (time of breath collection, type of container, breath fraction selected, the volume and route of breath), and after collection (storage of breath samples, VOCs stability).ResultsA total of 89 studies involving 6,409 individuals diagnosed with lung cancer were selected. The methods used to collect the breath varied substantially among the studies. A separate room was prepared for breath collection in 29 studies, the physiological state of the participants was described in 57 studies, and environmental considerations were reported in 41 studies. Polymer bags, specifically Tedlar bags, were the predominant choice for breath sample collection and were used in 58 out of the 89 studies. Alveolar breath was the most commonly selected breath fraction, which was used in 43 studies. Only 15 studies reported the storage conditions of the breath samples, which ranged from -40 ℃ to room temperature, and the stability of VOCs was recorded in 41 studies.ConclusionsThere is an urgent need for breath collection methods to be standardized to maximize the potential of this diagnostic approach. The summarized exhaled breath collection process proposed in this study based on included studies may serve as a method for future clinical research.

Dataset Information

Volatile Organic Compounds Analysis as a Potential Novel Screening Tool for Breast Cancer: A Systematic Review.

Introduction

Methods

Results

Discussion

Publications

Volatile Organic Compounds Analysis as a Potential Novel Screening Tool for Breast Cancer: A Systematic Review.

Similar Datasets

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