Self-selection vs Randomized Assignment of Treatment for Appendicitis.

ABSTRACT:

Importance

For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such trials compare with those of patients who select their treatment and whether outcomes differ.

Objective

To compare participants in the Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) randomized clinical trial (RCT) with a parallel cohort study of participants who declined randomization and self-selected treatment.

Design, setting, and participants

The CODA trial was conducted in 25 US medical centers. Participants were enrolled between May 3, 2016, and February 5, 2020; all participants were eligible for at least 1 year of f

SUBMITTER: Writing Group for the CODA Collaborative 

PROVIDER: S-EPMC9134042 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature