Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability.

ABSTRACT: Colorectal cancer is the second leading cause of cancer death worldwide, and the incidence of this disease is expected to increase as global socioeconomic changes occur. Immune checkpoint inhibition therapy is effective in treating a minority of colorectal cancer tumors; however, microsatellite stable tumors do not respond well to this treatment. Emerging cancer immunotherapeutic strategies aim to activate a cytotoxic T cell response against tumor-specific antigens, presented exclusively at the cell surface of cancer cells. These antigens are rare and are most effectively identified with a mass spectrometry-based approach, which allows the direct sampling and sequencing of these peptides. Although the few tumor-specific antigens identified to date are derived from coding regions of the gen

SUBMITTER: Cleyle J 

PROVIDER: S-EPMC9134101 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature