Identification of LSM Family Members as Novel Unfavorable Biomarkers in Hepatocellular Carcinoma.

ABSTRACT:

Background

Smith-like (LSM) family members play critical roles in multiple oncologic processes in several types of malignancies. The study on LSM family members of HCC might provide new insights into the tumorigenesis and therapeutic strategies of HCC.

Methods

The clinical significance and oncologic biological functions of LSM family members were assessed through multiple bioinformatics methods and in vitro studies. The potential correlation between LSM family members and tumor immunity was also investigated using single sample gene set enrichment analysis (ssGSEA) and the ESTIMATE algorithm.

Results

LSM family member overexpression in HCC was significantly correlated with poor clinical outcomes such as higher TNM stage, advanced histologic grade, and worse pro

SUBMITTER: Zhuang H 

PROVIDER: S-EPMC9134192 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature