Radiosensitivity of Breast Cancer Cells Is Dependent on the Organ Microenvironment.

ABSTRACT:

Background

Distant metastasis is the leading risk factor of death in breast cancer patients, with lung and liver being commonly involved sites of distant seeding. Ongoing clinical trials are studying the benefit from additional local treatment to these metastatic sites with radiation therapy. However, little is known about the tissue-specific microenvironment and the modulating response to treatments due to limitations of traditional in vitro systems. By using biomatrix scaffolds (BMSs) to recreate the complex composition of extracellular matrices in normal organs, we chose to study the radiotherapy response with engineered breast cancer "metastases" in liver and lung organ-specific tissues.

Methods

Liver and lung BMSs were prepared for tissue culture. Human breast ca

SUBMITTER: Guo G 

PROVIDER: S-EPMC9134193 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature