Discovery of new therapeutic targets in ovarian cancer through identifying significantly non-mutated genes.

ABSTRACT:

Background

Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are essential to tumor development could lead to new therapeutic strategies. The recent advent of high-throughput whole genome sequencing being applied to many different samples has made it possible to calculate if genes are significantly non-mutated in a specific cancer patient cohort.

Methods

We carried out random mutagenesis simulations of the human genome approximating the regions sequenced in the publicly available Cancer Growth Atlas Project for ovarian cancer (TCGA-OV). Simulated mutations were compared to the observed mutations in the TCGA-OV cohort and

SUBMITTER: Al-Farsi H 

PROVIDER: S-EPMC9134657 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature