An in vivo accelerated developmental myelination model for testing promyelinating therapeutics.

ABSTRACT:

Background

Therapeutic agents stimulating the process of myelination could be beneficial for the treatment of demyelinating diseases, such as multiple sclerosis. The efficient translation of compounds promoting myelination in vitro to efficacy in vivo is inherently time-consuming and expensive. Thyroid hormones accelerate the differentiation and maturation of oligodendrocytes, thereby promoting myelination. Systemic administration of the thyroid hormone thyroxine (T4) accelerates brain maturation, including myelination, during early postnatal development. The objective of this study was to validate an animal model for rapid testing of promyelinating therapeutic candidates for their effects on early postnatal development by using T4 as a reference compound.

Methods

Daily subc

SUBMITTER: Lariosa-Willingham K 

PROVIDER: S-EPMC9134688 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature