Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer's disease.

ABSTRACT:

Background

With a growing number of loci associated with late-onset (sporadic) Alzheimer's disease (AD), the polygenic contribution to AD is now well established. The development of polygenic risk score approaches have shown promising results for identifying individuals at higher risk of developing AD, thereby facilitating the development of preventative and therapeutic strategies. A polygenic hazard score (PHS) has been proposed to quantify age-specific genetic risk for AD. In this study, we assessed the predictive power and transferability of this PHS in an independent cohort, to support its clinical utility.

Results

Using genotype and imaging data from 780 individuals enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we investigated associations b

SUBMITTER: Vacher M 

PROVIDER: S-EPMC9134703 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature