DLEU1 promotes cell survival by preventing DYNLL1 degradation in esophageal squamous cell carcinoma.

ABSTRACT:

Background

Emerging evidence has highlighted the critical roles of long noncoding RNAs (lncRNAs) in tumor development and progression. However, the biological functions and underlying mechanisms of DLEU1 in esophageal squamous cell carcinoma (ESCC) remain unclear.

Methods

LncRNA expression in ESCC tissues was explored using lncRNA microarray datasets. The functional roles of DLEU1 in ESCC were demonstrated by a series of in vitro and in vivo experiments. RNA pull-down and immunoprecipitation assays were performed to demonstrate the potential mechanisms of DLEU1.

Results

In a screen for differentially expressed lncRNAs in ESCC, we determined that DLEU1 was one of the most overexpressed lncRNAs in ESCC tissues and that upregulated DLEU1 expression was associated with a

SUBMITTER: Li Q 

PROVIDER: S-EPMC9134706 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature