A novel biomarker panel index improves risk stratification after ischemic stroke.

ABSTRACT:

Background

We investigated 92 blood biomarkers implicated in the pathophysiological pathways of ischemic injury, inflammation, hemostasis, and regulation of vascular resistance to predict post-stroke mortality.

Aim

Based on the most promising markers, we aimed to create a novel Biomarker Panel Index (BPI) for risk stratification.

Methods

In this prospective study, we measured 92 biomarkers in 320 stroke patients. The primary outcome measure was mortality within 90 days. We estimated the association of each biomarker using logistic regression adjusting for multiple testing. The most significant 16 biomarkers were used to create the BPI. We fitted regression models to estimate the association and the discriminatory accuracy of the BPI with mortality and stroke etiology.

SUBMITTER: Bicvic A 

PROVIDER: S-EPMC9134784 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature