Human Macrophages Exhibit GM-CSF Dependent Restriction of <i>Mycobacterium tuberculosis</i> Infection <i>via</i> Regulating Their Self-Survival, Differentiation and Metabolism.

ABSTRACT: GM-CSF is an important cytokine that regulates the proliferation of monocytes/macrophages and its various functions during health and disease. Although growing evidences support the notion that GM-CSF could play a major role in immunity against tuberculosis (TB) infection, the mechanism of GM-CSF mediated protective effect against TB remains largely unknown. Here in this study we examined the secreted levels of GM-CSF by human macrophages from different donors along with the GM-CSF dependent cellular processes that are critical for control of M. tuberculosis infection. While macrophage of different donors varied in their ability to produce GM-CSF, a significant correlation was observed between secreted levels of GM-CSF, survial of macrophages and intra-macrophage control of Mycob

SUBMITTER: Mishra A 

PROVIDER: S-EPMC9134823 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature