Divergent properties and independent regulation of striatal dopamine and GABA co-transmission.

ABSTRACT: Substantia nigra pars compacta (SNc) dopamine neurons play a key role in regulating the activity of striatal circuits within the basal ganglia. In addition to dopamine, these neurons release several other transmitters, including the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). Both dopamine and GABA are loaded into SNc synaptic vesicles by the vesicular monoamine transporter 2 (VMAT2), and co-release of GABA provides strong inhibition to the striatum by directly inhibiting striatal medium spiny projection neurons (MSNs) through activation of GABA_A receptors. Here, we found that despite both dopamine and GABA being co-packaged by VMAT2, the properties of transmission, including Ca²⁺ sensitivity, release probability, and requirement of active zone scaff

SUBMITTER: Zych SM 

PROVIDER: S-EPMC9134867 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature