homeRNA: A Self-Sampling Kit for the Collection of Peripheral Blood and Stabilization of RNA.

ABSTRACT: Gene expression analysis (e.g., targeted gene panels and transcriptomics) from whole blood can elucidate mechanisms of the immune function and aid in the discovery of biomarkers. Conventional venipuncture offers only a small snapshot of our broad immune landscape as immune responses may occur outside of the time and location parameters available for conventional venipuncture. A self-operated method that enables flexible sampling of liquid whole blood coupled with immediate stabilization of cellular RNA is instrumental in facilitating capture and preservation of acute or transient immune fluxes. To this end, we developed homeRNA, a kit for self-collection of peripheral blood (∼0.5 mL) and immediate stabilization of cellular RNA, using the Tasso-SST blood collection device with

SUBMITTER: Haack AJ 

PROVIDER: S-EPMC9134895 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature