METTL3 promotes cell cycle progression via m⁶A/YTHDF1-dependent regulation of CDC25B translation.

ABSTRACT: The cell cycle machinery controls cell proliferation and the dysregulation of the cell cycle lies at the heart of carcinogenesis. Thus, exploring the unknown regulators involved in the cell cycle not only contribute to better understanding of cell proliferation but also provide substantial improvement to cancer therapy. In this study, we identified that the expression of methyltransferase METTL3 was upregulated in the M phase. Overexpression of METTL3 facilitated cell cycle progression, induced cell proliferation in vitro and enhanced tumorigenicity in vivo, while knockdown of METTL3 reversed these processes. METTL3 induced CDC25B mRNA m⁶A modification in the M phase, which accelerated the translation of CDC25B mRNA through YTHDF1-dependent m⁶

SUBMITTER: Li H 

PROVIDER: S-EPMC9134919 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature