Second primary malignancies in cervical cancer and endometrial cancer survivors: a population-based analysis.

ABSTRACT:

Background

We evaluated the relative attribution and interactions of treatment and patient-related risk factors for second primary malignancies (SPMs) in cervical and endometrial cancer survivors.

Methods

Stage I-III cervical and endometrial cancer survivors' data from the Surveillance, Epidemiology, and End Results (SEER) registry between January 1988 and December 2015 were analyzed. The standardized incidence ratio (SIR), excess absolute risk (EAR), and corresponding 95% confidence interval (95% CI) values were calculated. Analyses were classified based on proxies of human papillomavirus (HPV), smoking, hormone, and radiotherapy (RT) status. Additive and multiplicative interactions were assessed.

Results

Cervical cancer survivors had a higher risk for developing pot

SUBMITTER: Huang K 

PROVIDER: S-EPMC9134942 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature