Ferroptosis-related local immune cytolytic activity in tumor microenvironment of basal cell and squamous cell carcinoma.

ABSTRACT:

Background

Ferroptosis, a recently discovered form of cell death, whose role in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) has not been well disclosed. To improve our understanding of the differences in tumor progression and therapeutic effects between BCC and SCC, and to find potential therapeutic targets, this study systematically analyzed ferroptosis-related genes (FRGs) and their associated local immune cytolytic activity (LICA) and tumor microenvironment (TME) metabolic function differences.

Methods

Two bulk RNA-seq datasets, GSE7553 and GSE125285, from the Gene Expression Omnibus database were compared within and between groups to screen for common differentially expressed genes (DEGs) for enrichment analysis. The currently recognized FRGs in DEGs gen

SUBMITTER: Wang J 

PROVIDER: S-EPMC9134950 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature