RecQ mediated genome instability 2 (RMI2): a potential prognostic and immunological biomarker for pan-cancers.

ABSTRACT:

Background

RecQ mediated genome instability 2 (RMI2) is an essential component of the BLM-TopoIIIa-RMI1-RMI2 (BTR) complex. However, the mysterious veil of the potential immunological relationship of RMI2 in tumorigenesis and development has not been revealed.

Methods

We conducted the differential expression (DE) analysis of the RMI2 in pan-cancer using data onto Oncomine, TIMER, and GEPIA databases. Afterward, survival analysis and clinical-stage correlation analysis were performed via the TCGA database. Subsequently, we used R software to further explore the relationship between the expression level of RMI2 and tumor mutation burden (TMB), microsatellite instability (MSI), tumor microenvironment (TME), tumor immune-infiltrated cells (TILs

SUBMITTER: Wei W 

PROVIDER: S-EPMC9134953 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature