Prognostic value and immune characteristics of RUNX gene family in human cancers: a pan-cancer analysis.

ABSTRACT:

Background

Runt-related transcription factors (RUNX) are involved in numerous fundamental biological processes and play crucial parts in tumorigenesis and metastasis both directly and indirectly. However, the pan-cancer evidence of the RUNX gene family is not available.

Methods

In this study, we analyzed the potential association between RUNX gene family expression and patient's prognosis, immune cell infiltration, drug response, and genetic mutation data across different types of tumors using based on The Cancer Genome Atlas, Gene Expression Omnibus, and Oncomine database.

Results

The results showed that the expression of the RUNX gene family varied among different cancer types, revealing its heterogeneity in cancers and that expression of RUNX2

SUBMITTER: Zhao H 

PROVIDER: S-EPMC9134966 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature