Real-Time Detection and Capture of Invasive Cell Subpopulations from Co-Cultures.

ABSTRACT: Invasion and metastatic spread of cancer cells are the major cause of death from cancer. Assays developed early on to measure the invasive potential of cancer cell populations typically generate a single endpoint measurement that does not distinguish between cancer cell subpopulations with different invasive potential. Also, the tumor microenvironment consists of different resident stromal and immune cells that alter and participate in the invasive behavior of cancer cells. Invasion into tissues also plays a role in immune cell subpopulations fending off microorganisms or eliminating diseased cells from the parenchyma and endothelial cells during tissue remodeling and angiogenesis. Real-Time Cellular Analysis (RTCA) that utilizes impedance biosensors to monitor cell invasion was a major st

SUBMITTER: Sharif GM 

PROVIDER: S-EPMC9135070 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature