Renal Safety of Multimodal Brain Imaging Followed by Endovascular Therapy.

ABSTRACT:

Background and purpose

Contrast-enhanced noninvasive angiography and perfusion imaging are recommended to identify eligible patients for endovascular therapy (EVT) in extended time windows (>6 hours or wake-up). If eligible, additional intraarterial contrast exposure will occur during EVT. We aimed to study the renal safety in the DEFUSE 3 (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke) population, selected with contrast-enhanced multimodal Imaging and randomized to EVT versus medical management.

Methods

In the randomized DEFUSE 3 trial population, we compared changes in serum creatinine between baseline (before randomization) and 24 hours later. The primary outcome was the relative change in creatinine level between baseline and 24 hours in the EVT v

SUBMITTER: Cereda CW 

PROVIDER: S-EPMC9135171 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature