Multi-system trajectories and the incidence of heart failure in the Framingham Offspring Study.

ABSTRACT:

Background

Heart failure is a multi-system disease, with non-cardiac systems playing a key role in disease pathogenesis.

Objective

Investigate whether longitudinal multi-system trajectories incrementally predict heart failure risk compared to single-occasion traits.

Methods

We evaluated 3,412 participants from the Framingham Heart Study Offspring cohort, free of heart failure, who attended examination cycle 5 and at least one examination between 1995-2008 (mean age 67 years, 54% women). We related trajectories for the following organ systems and metabolic functions to heart failure risk using Cox regression: kidney (estimated glomerular filtration rate), lung (forced vital capacity and the ratio of forced expiratory volume in one second/forced vital capacity), neuromo

SUBMITTER: Guardino CE 

PROVIDER: S-EPMC9135195 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature