The longitudinal connection between depressive symptoms and inflammation: Mediation by sleep quality.

ABSTRACT: Although there is a strong association between depressive symptoms and markers of inflammation, it remains unclear whether depressive symptoms at one point in life may predict inflammation later in life. Moreover, despite extant literature linking sleep with both depressive symptoms and inflammation, there is little research investigating poor sleep as a mechanism linking depressive symptoms with later inflammation. The links between depression and physical health can also vary by gender. In longitudinal analyses with data from the Midlife in the United States (MIDUS) study, we examined whether depressive symptoms were associated with inflammatory markers 11 years later and whether these associations were mediated by sleep disturbances or moderated by gender. Participants reported depressi

SUBMITTER: Song S 

PROVIDER: S-EPMC9135207 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature