Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma.

ABSTRACT:

Objectives

Small proline-rich protein 1A (SPRR1A) is recognized as a squamous differentiation marker but is also upregulated in some non-squamous cancers. However, its expression in pancreatic ductal adenocarcinoma (PDAC) has not been investigated. This study elucidated the expression of SPRR1A in PDAC and its effect on the prognosis and malignant behavior of PDAC.

Methods

We examined the SPRR1A expression by immunohistochemistry in 86 surgical PDAC cases and revealed the relationship between its expression and the prognosis of the PDAC patients. Furthermore, we overexpressed SPRR1A in pancreatic cancer cell lines (PK-1 and Panc-1) and assessed the phenotype and gene expression changes in vitro.

Results

Among the 84 cases, excluding 2 with squamous differentiation, 31

SUBMITTER: Yamakawa K 

PROVIDER: S-EPMC9135243 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature