Analysis of cathepsin S expression in gastric adenocarcinoma and in Helicobacter pylori infection.

ABSTRACT:

Background

Recent experimental studies have suggested a potential link between cathepsin S (CTTS) and gastric adenocarcinoma progression. Herein, we aimed to evaluate the expression of CTTS in gastric adenocarcinoma in patients who underwent curative-intent surgical resection.

Methods

This was a cross-sectional study that included two groups: gastric adenocarcinoma (n = 42) and gastritis (n = 50). The gastritis group was then subdivided into H. pylori-positive (n = 25) and H. pylori-negative (n = 25) groups. Gastric tissue samples were analysed to determine CTTS expression through immunohistochemistry. Samples were obtained by oesophagogastroduodenoscopy or surgical specimens.

Results

In patients with gastritis, the age ranged from 18 to 78 years. Among them, 34% were

SUBMITTER: Costa AC 

PROVIDER: S-EPMC9135267 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature