Cardio PyMEA: A user-friendly, open-source Python application for cardiomyocyte microelectrode array analysis.

ABSTRACT: Open source analytical software for the analysis of electrophysiological cardiomyocyte data offers a variety of new functionalities to complement closed-source, proprietary tools. Here, we present the Cardio PyMEA application, a free, modifiable, and open source program for the analysis of microelectrode array (MEA) data obtained from cardiomyocyte cultures. Major software capabilities include: beat detection; pacemaker origin estimation; beat amplitude and interval; local activation time, upstroke velocity, and conduction velocity; analysis of cardiomyocyte property-distance relationships; and robust power law analysis of pacemaker spatiotemporal instability. Cardio PyMEA was written entirely in Python 3 to provide an accessible, integrated workflow that possesses a user-friendly graphica

SUBMITTER: Dunham CS 

PROVIDER: S-EPMC9135279 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature