Deviations from PRx-derived optimal blood pressure are associated with mortality after cardiac arrest.

ABSTRACT:

Aim

Pressure reactivity index (PRx) provides a surrogate measurement of cerebrovascular autoregulation (CAR). We determined whether deviations from PRx-derived optimal mean arterial pressure (MAP_opt) were associated with in-hospital mortality after adult cardiac arrest.

Methods

Retrospective analysis of post-cardiac arrest patients who had continuously recorded intracranial pressure (ICP) and MAP. PRx was calculated as a moving, linear correlation between ICP and MAP. Impaired CAR was defined as PRx ≥ 0.3. MAP_opt was calculated using a multi-window weighted algorithm. The burdens of MAP < 5 mmHg below MAP_opt (MAP_opt-5) and > 5 mmHg above MAP_opt (MAP_opt + 5) were calculated by integrating the area between MAP a

SUBMITTER: Kirschen MP 

PROVIDER: S-EPMC9135307 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature