The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17.

ABSTRACT: PAX8 is a master transcription factor that is essential during embryogenesis and promotes neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract, and its deletion during development results in atresia of reproductive tract organs. Nearly all ovarian carcinomas express PAX8, and its knockdown results in apoptosis of ovarian cancer cells. To explore the role of PAX8 in these tissues, we purified the PAX8 protein complex from nonmalignant fallopian tube cells and high-grade serous ovarian carcinoma cell lines. We found that PAX8 was a member of a large chromatin remodeling complex and preferentially interacted with SOX17, another developmental transcription factor. Depleting either PAX8 or SOX17 from cancer cells altered the expression of factors involv

SUBMITTER: Chaves-Moreira D 

PROVIDER: S-EPMC9135381 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature