Targeting the Essential Transcription Factor HP1043 of Helicobacter pylori: A Drug Repositioning Study.

ABSTRACT: Antibiotic-resistant bacterial pathogens are a very challenging problem nowadays. Helicobacter pylori is one of the most widespread and successful human pathogens since it colonizes half of the world population causing chronic and atrophic gastritis, peptic ulcer, mucosa-associated lymphoid tissue-lymphoma, and even gastric adenocarcinoma. Moreover, it displays resistance to numerous antibiotics. One of the H. pylori pivotal transcription factors, HP1043, plays a fundamental role in regulating essential cellular processes. Like other bacterial transcription factors, HP1043 does not display a eukaryote homolog. These characteristics make HP1043 a promising candidate to develop novel antibacterial strategies. Drug repositioning is a relatively recent strategy employed in drug d

SUBMITTER: Antoniciello F 

PROVIDER: S-EPMC9135449 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature