The association between pre-exposure to glucocorticoids and other immunosuppressant drugs with severe COVID-19 outcomes.

ABSTRACT:

Objectives

Whether preinfection use of immunosuppressant drugs is associated with COVID-19 severity remains unclear. The study was aimed to determine the association between preinfection use of immunosuppressant drugs with COVID-19 outcomes within 1 month after COVID-19 diagnosis.

Methods

This cohort study included individuals aged ≥18 years with underlying conditions associated with an immunocompromised state and diagnosed with COVID-19 between February 2020 and January 2021 at Karolinska University Hospital, Stockholm. Exposure to immunosuppressant drugs was defined based on dose and duration of drugs (glucocorticoids and drugs included in L01 or L04 chapter of Anatomical Therapeutic Chemical classification) before COVID-19 diagnosis. Outcomes included hospital admission,

SUBMITTER: Brodin R 

PROVIDER: S-EPMC9135501 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature