Lack of cognitive impairment in long-term survivors of colorectal cancer.

ABSTRACT:

Background

Our longitudinal study reported cognitive impairment in 43% of people following diagnosis of localised colorectal cancer (CRC) versus 15% in healthy controls (p < 0.001) and 50% versus 13% 1-2 years later (p < 0.001). Here we evaluate cognitive function and neuroimaging in a subgroup at long-term follow-up.

Patients and methods

Cancer-free Australian participants in the study, and controls, completed cognitive and functional assessments. Neuroimaging was optional. Blood tests included inflammatory markers, clotting factors, sex hormones and apolipoprotein E genotype. The primary endpoint was demographically and practice effect-corrected cognitive scores comparing CRC survivors with controls over time examined using a linear mixed model, adjusted for baseline perfo

SUBMITTER: Vardy JL 

PROVIDER: S-EPMC9135780 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature