The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants.

ABSTRACT: Vaccination against SARS-CoV-2 protects from infection and improves clinical outcomes in breakthrough infections, likely reflecting residual vaccine-elicited immunity and recall of immunological memory. Here, we define the early kinetics of spike-specific humoral and cellular immunity after vaccination of seropositive individuals and after Delta or Omicron breakthrough infection in vaccinated individuals. Early longitudinal sampling revealed the timing and magnitude of recall, with the phenotypic activation of B cells preceding an increase in neutralizing antibody titers. While vaccination of seropositive individuals resulted in robust recall of humoral and T cell immunity, recall of vaccine-elicited responses was delayed and variable in magnitude during breakthrough infections and depende

SUBMITTER: Koutsakos M 

PROVIDER: S-EPMC9135796 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature