Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life.

ABSTRACT: The prevalence of cardiovascular disease increases exponentially with age, highlighting the contribution of aging mechanisms to cardiac diseases. Although model organisms which share human disease pathologies can elucidate mechanisms driving disease, they do not provide us with innate examples how cardiac aging might be slowed or attenuated. The identification of animal models that preserve cardiac function throughout most of life offers an alternative approach to study mechanisms which might slow cardiac aging. One such species may be the naked mole-rat (NMR), a mouse-sized (40 g) rodent with extraordinary longevity (> 37 years), and constant mortality hazard over its four decades of life. We used a cross-sectional study design to measure a range of physiological parameters in NMRs betwee

SUBMITTER: Can E 

PROVIDER: S-EPMC9135933 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature