Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease.

ABSTRACT: Chronic kidney disease (CKD) is defined by a reduced estimated glomerular filtration rate (eGFR). This failure can be related to a phenotype of accelerated aging. In this work, we considered 76 patients with end-stage renal disease (ESRD) and 83 healthy controls. We concomitantly evaluated for the first time two measures that can be informative of the rate of aging, i.e., whole blood DNA methylation using the Illumina Infinium EPIC array and plasma levels of a selection of inflammatory/immunological proteins using multiplex immunoassays. First of all, we demonstrated accelerated aging in terms of the most common epigenetic age estimators in CKD patients. Moreover, we developed a new clock/predictor of age based on the inflammatory/immunological profile (ipAGE) and identified the inflammato

SUBMITTER: Yusipov I 

PROVIDER: S-EPMC9135940 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature