A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans.

ABSTRACT: In populations around the world, the fraction of humans aged 65 and above is increasing at an unprecedented rate. Aging is the main risk factor for the most important degenerative diseases and this demographic shift poses significant social, economic, and medical challenges. Pharmacological interventions directly targeting mechanisms of aging are an emerging strategy to delay or prevent age-dependent diseases. Successful application of this approach has the potential to yield dramatic health, social, and economic benefits. Psora-4 is an inhibitor of the voltage-gated potassium channel, Kv1.3, that has previously been shown to increase longevity and health span in the nematode Caenorhabditis elegans (C. elegans). Our recent discovery that Psora-4 lifespan benefits in C. elegans are synergis

SUBMITTER: Admasu TD 

PROVIDER: S-EPMC9135947 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature