Single Cell Transcriptome and Surface Epitope Analysis of Ankylosing Spondylitis Facilitates Disease Classification by Machine Learning.

ABSTRACT: Ankylosing spondylitis (AS) is an immune-mediated inflammatory disorder that primarily affects the axial skeleton, especially the sacroiliac joints and spine. This results in chronic back pain and, in extreme cases, ankylosis of the spine. Despite its debilitating effects, the pathogenesis of AS remains to be further elucidated. This study used single cell CITE-seq technology to analyze peripheral blood mononuclear cells (PBMCs) in AS and in healthy controls. We identified a number of molecular features associated with AS. CD52 was found to be overexpressed in both RNA and surface protein expression across several cell types in patients with AS. CD16⁺ monocytes overexpressed TNFSF10 and IL-18Rα in AS, while CD8⁺ T_EM cells and natural killer cells ove

SUBMITTER: Alber S 

PROVIDER: S-EPMC9135966 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature