Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study.

ABSTRACT:

Background

Childhood obesity has important effects on the onset and development of puberty. Although a number of studies have confirmed the relationship between obesity and precocious puberty, little is known about the pleiotropic genes of obesity and precocious puberty and the interaction between genes and environment. There are four objectives: (1) to analyze the incidence of precocious puberty in the general population in China; (2) to verify the direct effect of obesity on children's precocious puberty using a variety of methods; (3) to verify the effect of obesity and its risk gene polymorphism on precocious puberty in a prospective cohort study; and (4) to analyze the interaction effect of genes and environment on pubertal development.

Methods

We will conduct a multi-c

SUBMITTER: Yu T 

PROVIDER: S-EPMC9135982 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature