U1A is a positive regulator of the expression of heterologous and cellular genes involved in cell proliferation and migration.

ABSTRACT: Here, we show that direct recruitment of U1A to target transcripts can increase gene expression. This is a new regulatory role, in addition to previous knowledge showing that U1A decreases the levels of U1A mRNA and other specific targets. In fact, genome-wide, U1A more often increases rather than represses gene expression and many U1A-upregulated transcripts are directly bound by U1A according to individual nucleotide resolution crosslinking and immunoprecipitation (iCLIP) studies. Interestingly, U1A-mediated positive regulation can be transferred to a heterologous system for biotechnological purposes. Finally, U1A-bound genes are enriched for those involved in cell cycle and adhesion. In agreement with this, higher U1A mRNA expression associates with lower disease-free survival and overa

SUBMITTER: Rovira E 

PROVIDER: S-EPMC9136276 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature