Ontology highlight
ABSTRACT:
SUBMITTER: Rovira E
PROVIDER: S-EPMC9136276 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Rovira Eric E Moreno Beatriz B Razquin Nerea N Hjerpe Roland R Gonzalez-Lopez Monika M Barrio Rosa R Ruiz de Los Mozos Igor I Ule Jernej J Pastor Fernando F Blazquez Lorea L Fortes Puri P
Molecular therapy. Nucleic acids 20220510
Here, we show that direct recruitment of U1A to target transcripts can increase gene expression. This is a new regulatory role, in addition to previous knowledge showing that U1A decreases the levels of U1A mRNA and other specific targets. In fact, genome-wide, U1A more often increases rather than represses gene expression and many U1A-upregulated transcripts are directly bound by U1A according to individual nucleotide resolution crosslinking and immunoprecipitation (iCLIP) studies. Interestingl ...[more]