Can the presence of KRAS mutations guide the type of liver resection during simultaneous resection of colorectal liver metastasis?

ABSTRACT:

Backgrounds/aims

It is generally accepted that non-anatomical resection (NAR) in colorectal liver metastasis (CRLM) has comparable safety and efficacy compared to anatomical resection (AR); however, there are reports that AR may have better outcomes in KRAS mutated CRLM. This study aimed to determine the effects of KRAS mutations and surgical techniques on survival outcomes in CRLM patients.

Methods

Two hundred fifty patients who underwent hepatic resection of CRLM with known KRAS mutational status between 2007 and 2018 were analyzed. A total of 94 KRAS mutated CRLM and 156 KRAS wild-type CRLM were subdivided by surgical approach and compared for short- and long-term outcomes.

Results

In both KRAS wild-type and mutated type, there was no difference in estimated

SUBMITTER: Choi M 

PROVIDER: S-EPMC9136426 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature