FGF6 promotes cardiac repair after myocardial infarction by inhibiting the Hippo pathway.

ABSTRACT:

Objectives

Myocardial infarction (MI) commonly occurs in patients with coronary artery disease and have high mortality. Current clinical strategies for MI still limited to reducing the death of myocardial cells but failed to replace these cells. This study aimed to investigate the role of fibroblast growth factor 6 (FGF6) in enhancing the proliferative potential of cardiomyocytes (CMs) after ischemic injury via the Hippo pathway.

Materials and methods

Expression of FGF6 protein was analysed in mice with MI induced by ligation of the left anterior descending coronary artery. Activation of the Hippo pathway and the proliferation potential were examined in ischemic CMs, treated with FGF6 protein or transfected with an adeno-virus carrying FGF6 sh-RNA. Immunofluorescence stainin

SUBMITTER: Hu Z 

PROVIDER: S-EPMC9136516 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature