Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases.

ABSTRACT: Cardiometabolic disease (CMD), characterized with metabolic disorder triggered cardiovascular events, is a leading cause of death and disability. Metabolic disorders trigger chronic low-grade inflammation, and actually, a new concept of metaflammation has been proposed to define the state of metabolism connected with immunological adaptations. Amongst the continuously increased list of systemic metabolites in regulation of immune system, bile acids (BAs) represent a distinct class of metabolites implicated in the whole process of CMD development because of its multifaceted roles in shaping systemic immunometabolism. BAs can directly modulate the immune system by either boosting or inhibiting inflammatory responses via diverse mechanisms. Moreover, BAs are key determinants in maintai

SUBMITTER: Guan B 

PROVIDER: S-EPMC9136572 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature