Exposure to Intrapartum Epidural Analgesia and Risk of Autism Spectrum Disorder in Offspring.

ABSTRACT:

Importance

There is conflicting evidence on the association between intrapartum epidural analgesia and risk of autism spectrum disorder (ASD) in offspring.

Objective

To evaluate the association between intrapartum epidural analgesia and the risk of ASD in offspring.

Design, setting, and participants

This population-based cohort study was conducted in Ontario, Canada, using the health and administrative records of singleton live births by vaginal delivery between April 1, 2006, and March 31, 2014. Neonates with less than 24 weeks' gestation or weighing less than 500 g were excluded. Offspring were followed up from 18 months of age until ASD diagnosis, loss to follow-up, or the end of the study (December 31, 2020), whichever occurred first. Exposure, covariate, and outc

SUBMITTER: Murphy MSQ 

PROVIDER: S-EPMC9136620 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature