Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.

ABSTRACT:

Importance

Developing interventions against age-related memory decline and for older adults experiencing neurodegenerative disease is one of the greatest challenges of our generation. Spermidine supplementation has shown beneficial effects on brain and cognitive health in animal models, and there has been preliminary evidence of memory improvement in individuals with subjective cognitive decline.

Objective

To determine the effect of longer-term spermidine supplementation on memory performance and biomarkers in this at-risk group.

Design, setting, and participants

This 12-month randomized, double-masked, placebo-controlled phase 2b trial (the SmartAge trial) was conducted between January 2017 and May 2020. The study was a monocenter trial carried out at an academic cli

SUBMITTER: Schwarz C 

PROVIDER: S-EPMC9136623 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature