Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues.

ABSTRACT: Recent reports have challenged the notion that the lens is immune-privileged. However, these studies have not fully identified the molecular mechanism(s) that promote immune surveillance of the lens. Using a mouse model of targeted glutathione (GSH) deficiency in ocular surface tissues, we have investigated the role of oxidative stress in upregulating cytokine expression and promoting immune surveillance of the eye. RNA-sequencing of lenses from postnatal day (P) 1-aged Gclc^f/f;Le-Cre^Tg/- (KO) and Gclc^f/f;Le-Cre^-/- control (CON) mice revealed upregulation of many cytokines (e.g., CCL4, GDF15, CSF1) and immune response genes in the lenses of KO mice. The eyes of KO mice had a greater number of cells in the aqueous and vitreous humors at P1, P20 an

SUBMITTER: Thompson B 

PROVIDER: S-EPMC9136680 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature