Modification of small dissolution chamber system for long-acting periodontal drug product evaluation.

ABSTRACT: Conventional dissolution testing methods may not be suitable for long-acting periodontal drug products due to the small volume, slow fluid flow rate, and environment in the periodontal pocket. The objective of this study was to evaluate a 3D-printed small volume flow-through dissolution chamber system (modified from a previous study) for biorelevant and dose-discriminating testing. Three periodontal drug products with different dosage forms were tested: Atridox, Arestin, and PerioChip. Modifications were made to suit the specific characteristics of these dosage forms. No significant differences were observed between the % drug release profiles in vitro and in vivo except for Atridox. The differences observed with Atridox could be related to the exposing surface area of the drug product. Si

SUBMITTER: Wanasathop A 

PROVIDER: S-EPMC9136688 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature