Changes in truncal obesity and fat distribution predict arterial health.

ABSTRACT:

Background

Truncal obesity is associated with metabolic syndrome and cardiovascular risk. Although vascular health is influenced by weight, it is not known whether changes in fat distribution modulate arterial function.

Objective

We assessed how changes in truncal (android) fat at 1 year affect arterial stiffness and endothelial function.

Methods

We recruited 711 healthy volunteers (235 males, age 48 ± 11 years) into the Emory Predictive Health Study; 498 returned at 1 year. Measurements included anthropometric and chemistry panels, fat mass using dual-energy X-ray absorptiometry, arterial stiffness indices (pulse wave velocity [PWV], augmentation index [AIx], and subendocardial viability ratio [SEVR]; Sphygmocor), flow-mediated dilation (FMD), and reactive hyperemia

SUBMITTER: Corrigan FE 

PROVIDER: S-EPMC9136712 | biostudies-literature | 2017 Nov - Dec

REPOSITORIES: biostudies-literature