Setomimycin as a potential molecule for COVID‑19 target: in silico approach and in vitro validation.
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ABSTRACT:
SUBMITTER: Manhas RS
PROVIDER: S-EPMC9136828 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
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Setomimycin as a potential molecule for COVID‑19 target: in silico approach and in vitro validation.
Manhas Ravi S RS Tiwari Harshita H Noor Mateen M Ahmed Ajaz A Vishwakarma Jyoti J Tripathi Raja B M RBM Ramachandran Ravishankar R Madishetti Sreedhar S Mukherjee Debaraj D Nargotra Amit A Chaubey Asha A
Molecular diversity 20220527 2
COVID-19 pandemic caused by the SARS-CoV-2 virus has led to a worldwide crisis. In view of emerging variants time to time, there is a pressing need of effective COVID-19 therapeutics. Setomimycin, a rare tetrahydroanthracene antibiotic, remained unexplored for its therapeutic uses. Herein, we report our investigations on the potential of setomimycin as COVID-19 therapeutic. Pure setomimycin was isolated from Streptomyces sp. strain RA-WS2 from NW Himalayan region followed by establishing in sili ...[more]
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