Insulin resistance persists despite a metabolically healthy obesity phenotype.

ABSTRACT:

Objective

Metabolically healthy obesity (MHO) is often defined as the absence of metabolic syndrome in the presence of obesity. However, phenotypic features of MHO are unclear. Insulin sensitivity in MHO was cross-sectionally compared with metabolically unhealthy obesity (MUO) and a reference group of young healthy participants without obesity.

Methods

Sedentary adults (n = 96) undergoing anthropometric, blood chemistries, maximal aerobic capacity, and euglycemic-hyperinsulinemic clamp measurements were classified by BMI (<25 and ≥30 kg/m² ). MUO was defined as having obesity with metabolic syndrome (≥2 additional risk factors). Data were analyzed using a linear mixed models approach.

Results

Body weight was similar between MHO and MUO. Body fat (percentage

SUBMITTER: Hoddy KK 

PROVIDER: S-EPMC9136885 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature